APEs are also components of biocides, plastics, and paints. 1 0 obj In another in vivo experiment of mammary tumorigenesis, fetal exposure to 4-normal-OP (4-n-OP) enhanced the induction of mammary tumors induced by DMBA in rats [93]. Total RNAs were extracted in a time-dependent manner (0, 6, and 24h). To evaluate the effects of TCS and OP breast cancer growth, MCF-7 cells were transplanted into female BALB/c nude mice. &@Iqe~eo9ycfJSmKi]bQpc/0 n^>24by0Y+ If not, click 'cancel'. Altered expression levels of TGF-R1 gene and TGF-R2 gene following treatments with E2, OP, or NP. Contact with eyes causes irritation. ]gk5f]Nan ) The substance entered Annex XIV of REACH for its endocrine disrupting properties. Since 1975, Dr. Ehrenstorfer has led the way in producing pesticide reference standards. NP affected both male (decreased epididymal sperm density and testicular spermatid head counts) and female (increased estrus cycle length and decreased ovarian weights) rats in multigeneration tests [2]. The other three chemicals are currently under data analysis, and risk assessment of these chemicals will be conducted in the near future. : {{entry.product.biosafetyLevel == -1 ? Data represent the meansS.D. Slvio VazJr., in Analysis of Chemical Residues in Agriculture, 2021. In stromal cells, ER was expressed from PND 6 in both groups without any PCNA positive cells, but significantly lower values were noted in the OP-treated group up to PND 10. Whichever authorisation route chosen, "risk management" or "socio-economic analysis" (SEA), EcoMundo recommends to create an SEA dossier in case the relevance of the threshold demonstration is questioned by the committee assessors. 1.5, in which the increase in cell growth induced by 4-tert-OP was restored to the control level as a result of ER inactivation by ICI 182,780. Estrogenic effects of industrial chemicals such as bisphenol-A, Assessment strategies of endocrine disrupters under regulations of the Ministry of the Environment of Japan, Neuroendocrine Regulation of Animal Vocalization, MEOGRT of a Tier 2 test was applied to four chemicals, 4-, Endocrine disruptors in human milk and the health-related issues of breastfeeding, Bisphenol A (BPA), a primary monomer in polycarbonate plastic and epoxy resins, and. Product code: {{entry.product.displayPartCode ? The impacts of NP in the environment include feminization of aquatic organisms, decrease in male fertility, and the survival of juveniles at concentrations as low as 8.2g/L [81]. reported that polystyrene tubes used in routine laboratory procedures released a substance with estrogenic properties and identified the substance as a nonylphenol. 3 0 obj Estrogenic effects of industrial chemicals such as bisphenol-A, nonylphenol, and octylphenol have been identified using cell proliferation of estrogen-responsive human breast cancer cells in in vitro and in vivo induction of vitellogenin (egg yolk precursor protein) in male fish [2]. NP has estrogenic activity by binding to estrogen receptors (ERs) in both in vitro and in vivo assay systems. Chemicals having anti-thyroid hormone activity have also been reported, using amphibian metamorphosis assay [5,6]. B.G.J. In in vitro and in vivo testicular cancer cell proliferation assay, the nanomolar range of a realistic mixture of 4-tertiary-OP (4-tert-OP) and 4-NP, which corresponds to environmental doses, promoted a maximum proliferation increase of seminoma-derived (TCam-2) and embryonal carcinoma (NT2/D1) cell lines, via CREB-phosphorylation through a rapid, ER36-PI3 kinase nongenomic pathway [75]. PND 14, the second week of life, is coincident with the normal time for differentiation when the luminal epithelium invaginates into the stroma to form uterine glands. In vitro reporter gene assay revealed that relative potency of NP to estradiol-17 for medaka estrogen receptor is 0.5% [7]. Gas and liquid chromatography coupled to mass spectrometers are still predominant technologies for analysis of the targets, but the supercritical fluid chromatography coupled to tandem mass spectrometer that has emerged recently may become an alternative method. ;U[.Q6RmumP* e=A_RUIY-2;GeV7nUk].eIV^}V`` En!A!PvVi ?7#b *`oj^*/2YGReu64}?2|d"/_"Y ?UQ!6Ne7t(t0S'skvi+oBF1~H]UVUZwP^^F=>O %PDF-1.4 entry.product.displayPartCode : entry.product.code}}, Biosafety Level Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that they fully comply with all applicable biosafety and biomaterial regulations in their country. More recent research demonstrated bioaccumulation by freshwater macroalgae (Cladophora glomerata) and microalgae (Chlorella vulgaris) and consequent biomagnification in fathead minnow and subsequent trophic levels (Sun et al., 2014). APEs are surfactants that are used in domestic and industrial detergents such as de-resinating agents, wetting agents, and degreasers. In addition to fetal exposure to 4-n-OP, neonatal exposure to 4-tert-OP also caused abnormal expression of ER and subsequent alteration of cell proliferating activity in the developing Donryu rat uterus [94]. Extraction techniques for nonylphenols (NPs) and nonylphenol ethoxylates (NPEOs) using solid sorbents for chromatographic analyses. Bioaccumulation of nonylphenol in mussels (Mytilus edulis) has also been known for at least three decades (Commission of the European Communities, 1991). E.g. When administered with a diet mixed with 10, 100, or 1000ppm of 4-n-OP throughout the pregnancy period and given 10mg DMBA by gastric intubation 50 days after birth, fetal exposure to 100 and 1000ppm 4-n-OP enhanced the early incidence and number of mammary carcinomas while it did not enhance the incidence and number of benign proliferative lesions, implying the mammary cancer risk imposed by the fetal exposure of 4-n-OP during pregnancy. Via expert services and software, we support the launch of industrial products, enabling companies to manage risks relating to chemical substances. National Oceanic and Atmospheric Administration. Recently, it was demonstrated that NP accelerates growth of MCF-7 breast cancer cells by regulating the expression of cell cycle-related genes such as cyclin D1 and p21 and promotes cancer metastasis through amplification of cathepsin D, a lysosomal aspartyl protease involved in tumor metastasis, via ER signaling [90]. Key elements of a successful authorisation dossier: A specific request with the most elements possible in relation to your, The Latest Application date for this substance is 4 July 2019, the last. OP-treatment, however, delayed and inhibited gland-formation and suppressed ER expression in the invaginated-luminal and glandular epithelium at this time. NONYLPHENOL ETHOXYLATES are polyethers. Read more. In addition to the CSR and Analysis of Alternatives, the applicant will have to conduct a socio-economic analysis for the dossier. The deadline for the implementation of IFRA 49 is fast approaching, are you ready? ScienceDirect is a registered trademark of Elsevier B.V. ScienceDirect is a registered trademark of Elsevier B.V. After receiving your order confirmation, please contact us using the 'Contact us' form. In MCF-7 breast cancer cells, TGF--mediated transcriptional activity was inhibited by estrogen [86]. Recently, an in vitro study has shown that alkylphenol compounds, such as OP and NP, are very potent estrogenic agents, and the binding affinity ERs to OP is approximately 1000-fold less than that of estrogen [79]. Please add to your cart and checkout as normal. Regulations Nonylphenol (NP) has not been widely used in commercial products, except in limited applications such as mixed with diisobutyl phthalate to color fuel oil for taxation purposes. Lower Explosive Limit (LEL): data unavailable, Upper Explosive Limit (UEL): data unavailable, Autoignition Temperature: data unavailable, Vapor Density (Relative to Air): data unavailable, Ionization Energy/Potential: data unavailable. According Li, Jin, and Snyder (2018), the analysis of nonylphenols (NPs) and their precursors NP ethoxylates (NPEOs) (Fig. Figure 1.4. Chemicals/Toxicology o,p-DDT was known to have estrogenic activity in the 1950s [7]. Although it has been shown that the concentration of NP in the environment is decreasing after the use, and production of such NP and NPEs have been banned in EU countries and strictly monitored in many other countries such as Canada and Japan, it is still found at concentrations of 4.1g/L in river waters and 1mg/kg in sediments [81]. In 1991, Soto et al. No rapid reaction with air. This study suggested that 4-tert-OP and 4-NP have the potential to enhance cancer progression in estrogen-responsive organs including ovary by manifesting an estrogenic effect in inhibiting TGF- signaling. Authors highlighted the need for in-depth study of the isomer-specific toxicity, with the individual analysis of NPEO homologs and their degradation product NP isomers. Prolonged contact with skin causes irritation. This lowest observed effect concentration was approximately twice as high as the maximum ambient aquatic concentration of 0.69g/L (sum of 4-nonylphenol branched isomers) detected in the Water Quality Survey of Public Water Bodies. By entering your email address, you confirm that you give your consent to LGC to share information in connection with the product(s) above and other similar products from time to time. Kim, in Encyclopedia of Toxicology (Third Edition), 2014. Overexpression of cathepsin D induced by estrogen is frequently observed as a feature of metastatic breast cancer [91]. These nonionic surfactants are used as oil-soluble detergents and emulsifiers, lubricants, oil additives, and antioxidants for rubber manufacture. Nonylphenol (NP; CAS: 25154-52-3, 84852-15-3, 104-40-5, 136-83-4, 11066-49-2) is a synthetic organic chemical produced in large volumes worldwide. Nhsitez pas nous laisser un commentaire ! Office of Response and Restoration, 4-Nonylphenol and REACH authorisation: what you must know, Tetramethylbutyl phenol, ethoxylated and REACH authorisation: what you must know, Coal tar pitch and REACH authorisation: what you must know, Bis(2-methoxyethyl) phthalate and REACH authorisation: what you must know. Our experts give you key information on this substance, as well as advice to follow before going ahead. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. bR3WxU''*yK134NA{+Qi{&tyJgK8wRkM}S6}6lWRNbK/>?D9zJ%`A9?% G!*BZ>o Pa"3]EQSsj The action of 4-tert-OP via ER mediation was definitely proved by cotreatment of fulvestrant (ICI 182,780), a typical ER antagonist, as shown in Fig. {{{aNBjJuV=M;?G>}wl* EXF VRk+AO31@&mnQ65l?8X_]OOzC% jHi~ Uo(kjjjlldl[0Y:8!Nb(o>?r Sumpter and Jobling suggested that NP contained in effluent from sewage treatment works is associated with vitellogenesis in male rainbow trout [5]. May float or sink in water. UdH?_Shcmh\I771L/? % Shinichi Miyagawa, Taisen Iguchi, in Handbook of Hormones, 2016. 5n.w/8qegfhFV(4=pgjVSs*7|qwz_cr1faFB wg/l;}onGgCedI;h/oy\smic$N bRH7T 5 0 obj 4-tert-OP was also revealed to accelerate MCF-7 breast cancer growth in cellular and xenografted mouse model by regulating cell cycle-related genes through an ER-mediated pathway [92]. endobj Kyung-A. In an in vitro cellular model using BG-1 ovarian cancer cell line, 4-tert-OP and 4-NP promoted cell growth by inhibiting TGF- signaling via downregulation of TGF- R2, instead of TGF- R1, and upregulation of c-myc oncogene, which was mediated by upregulation of ER signaling pathway as seen in Fig. In 20 human milk samples from the US, BPA, o-phenylphenol (OPP) and 2-hydroxy-4-methoxybenzophenone (BP-3) were detected in more than 60% of the samples tested. Triton or 4-Nonylphenol, branched and linear, ethoxylated, 4-Nonylphenol, branched and linear, ethoxylated [substances with a linear and/or branched alkyl chain with a carbon number of 9 covalently bound in position 4 to phenol, ethoxylated covering UVCB- and well-defined substances, polymers and homologues, which include any of the individual isomers and/or combinations thereof], Intrinsic property for which it was included in Annex XIV of REACH, Latest date to submit the authorisation dossier to ECHA. 7.6). Yolk-sac Atlantic salmon fry exposed to waterborne E2 (2g/L) or NP (10g/L) for 21 days and raised for one year in clean freshwater experienced higher mortality than unexposed fish during grow-out in freshwater (Lerner et al., 2007). hiiS?$3BVhOV},`aFF {nSuT@6!C ?jW(.#|>M]A{/j e~o,.FCd~Td;ZUsWTU5 y~}c6e0j:BK[PrX:qQ3?.*luvbO SLg In in vivo experiments, nonylphenol was found to induce vitellogenins (female egg yolk proteins) in the male liver at 20.3g/l in rainbow trout, and at 11.6g/l in medaka [8,9]. NP is toxic to aquatic organisms. Notice: A non well formed numeric value encountered in _responsive_image_build_source_attributes() (line 405 of core/modules/responsive_image/responsive_image.module). Read more, Bis(2-methoxyethyl) phthalate was included in Annex XIV of REACH on 14th June 2017. CBD in food supplements: how to comply in the EU? Expression level of TGF-R1 and TGF-R2 was detected by using semiquantitative reverse-transcription PCR. Explore our reference standards supporting COVID-19 testing. It will be banned in Europe from 4 July 2019, unless a REACH authorisation application has been drafted. These results demonstrate neonatal effects of a high dose of OP, already detectable at PND 10, with early and enhanced ER expression, resulting in an increase of cell proliferative activity in the luminal epithelium, though expression in the glandular epithelium was suppressed in relation to inhibited gland genesis. 10 things to know about cosmetics regulation in the U.S. including trade names and synonyms. By continuing you agree to the use of cookies. 17-Ethinylestradiol, synthesized for contraceptive pills and equilins used for hormone replacement therapy, have been found in river water in various countries, including the UK [5,6].

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4-nonylphenol branched ethoxylated